Stem cell mobilization

Stem cell mobilization is a process whereby stem cells are stimulated out of the bone marrow space (eg, the hip bones and the chest bone) into the bloodstream so they are available for collection for future reinfusion. The cells are then preserved, frozen, and stored until the time of transplant.

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What makes a successful mobilization?

Some preferred characteristics of a mobilization regimen include:

Mobilizing enough stem cells for transplant. This allows for recovery of red blood cells (RBCs), white blood cells (WBCs), and platelets when the stem cells are reinfused into your body
Minimizing the number of days of apheresis (cell separation)
Reaching target collection of stem cells in the first mobilization attempt
Shortening the time to hematopoietic cell transplantation (HCT)

What factors affect mobilization?

Some patients are unable to collect the target number of stem cells with mobilization strategies. There are a number of reasons for not collecting enough stem cells, and these may include:

Increased age
Receipt of prior treatment regimens and cycles

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